SB 202190

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SB 202190 (SB202190, SB-202190) 是一种有效的 p38α 和 p38β 抑制剂，IC50 分别为 50 nM 和 100 nM。

SB 202190 (SB202190, SB-202190) is a potent inhibitor p38α and p38β with IC50 of 50 nM and 100 nM respectively; stimulates the activity of CPP32-like caspases, potentiates apoptosis induced by Fas(APO-1) ligation or UV irradiation.(In Vitro):SB 202190 (0-10 μM; 0-72 hours) attenuates growth of a subgroup of CRC cell lines such as RKO, CACO2 and SW480 in a dose- and time-dependent manner.SB 202190 strongly inhibited colony formation and anchorage-independent growth (10 μM for 7–10 days) and elevated apoptotic cell death (10 μM for 72 h) in this same subset of CRC lines (RKO, CACO2 and SW480).In RKO, CACO2 and SW480 cells, SB202190 (10 μM; 2 hours) abrogates phosphorylation of S6K1(T389) and S6(S235/236), but not AKT(S473), indicating that p38i selectively blocks mTORC1 signaling.(In Vivo):SB 202190 (5 mg/kg; intraperitoneal injection; daily for 10-12 days) shows inhibition of tumor cell survival and tumor growth.

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Animal Model:4-week-old female BALB/c nude mice (bearing SW480 and RKO xenograft tumors)Dosage:5 mg/kg Administration:Intraperitoneal injection; daily for 10-12 daysResult:Inhibition of tumor cell survival and tumor growth.

SB202190 | SB-202190

MAPK/ERK Signaling

p38 MAPK

p38α|p38β

Cancer

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152121-30-7

331.343

C20H14FN3O

>98% (HPLC)

DMSO: ≥ 40 mg/mL

OC1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1

Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-

(-20℃)

With Ice Pack

≥ 2 years